STAFFORDSHIRE BULL TERRIERS INFO - STAFFSVILLE SBT REDS INFORMATION, STAFFORDSHIRE BULL TERRIER INFO ON BREED PHPV, HC, L2-HGA.         STAFFORDSHIRE BULL TERRIERS INFO ON STAFFSVILLE BREEDERS FROM SHETLAND, SCOTLAND ONE OF THE BEST UK STAFFORDSHIRE BULL TERRIER RED BLOOD LINES IN EUROPE BREEDING THE FINEST SBT REDS, STAFFORDSHIRE BULL TERRIER PUPPIES TESTING CLEAR OF PHPV, HC & L2-HGA.         About Staffsville and our Staffordshire Bull Terriers Information. We first got into Stafford's around ten years ago through the help of Abe Harkness of the world renown Senkrah kennels, acquiring a bitch puppy with predominantly Senkrah breeding. Since then through carefully selective breeding we have come to produce quality Staffsville puppies. we are Britain's most northerly breeders and exhibitors and there is around forty Stafford's on the islands of Shetland ,off which thirty two of them come from Staffsville breeding. Our dogs have been lightly shown and placed at all levels of shows from champ to limit shows and we try to breed as close to the standard as possible. We are the most northerly Breeder and Exhibitors of SBT in the Untied Kingdom Puppy and stud enquires are always welcome to carefully selected owners.           "Lennox"     Walbert Red Highlander X Seastaff Scarlet Ribbon " Ruby" Pjays Ruby Red Staffsville     Pensmith Billy Boy X Arnies Bella 24/5/03     Typical Staffsville Puppies.     This is a new website but will be updated daily if required by Aberdeen Website Design. If you require and information regarding our Staffordshire Bull Terriers or you wish to contact us for breed advice then please feel free to do so, our details are as follows and can you please enter your names, dogs name, where you live in the world and your questions if you want your questions published on this Staffordshire Bull Terriers Information Website? Mr.Scott and Muriel Forbes. Staffsville, Port Arthur, Scalloway, Shetland, UK. Email:Mail@staffsville.co.uk     Lotti Staffsville Lady Merlot CH Pennsmith Master Billy Boy X Pjays Red Ruby Staffsville. Just to let my visitors know there is a planned mating in December 2007 staffsville lady merlot x ch baysend nice one cyril.     STAFFORDSHIRE BULL TERRIERS, SBT HEALTH INFORMATION AND ISSUES REGARDING L2-HGA. L2-HGA Information. L-2-HGA (L-2-hydroxyglutaric aciduria) in Staffordshire Bull Terriers is a neurometabolic disorder characterized by elevated levels of L-2-hydroxyglutaric acid in urine, plasma and cerebrospinal fluid. L-2-HGA affects the central nervous system, with clinical signs usually apparent between 6 months and one year (although they can appear later). Symptoms include epileptic seizures, "wobbly" gait, tremors, muscle stiffness as a result of exercise or excitement and altered behavior. The mutation, or change to the structure of the gene, probably occurred spontaneously in a single dog but once in the population has been inherited from generation to generation like any other gene. The disorder shows an autosomal recessive mode of inheritance: two copies of the defective gene (one inherited from each parent) have to be present for a dog to be affected by the disease. Individuals with one copy of the defective gene and one copy of the normal gene - called carriers - show no symptoms but can pass the defective gene onto their offspring. When two apparently healthy carriers are crossed, 25% (on average) of the offspring will be affected by the disease, 25% will be clear and the remaining 50% will themselves be carriers The mutation responsible for the disease has recently been identified at the Animal Health Trust. Using the information from this research, we have developed a DNA test for the disease. This test not only diagnoses dogs affected with this disease but can also detect those dogs which are carriers, displaying no symptoms of the disease but able to produce affected pups. Carriers could not be detected by the tests previously available which involved either a blood or urine test detecting elevated levels of L-2-hydroxyglutarate or magnetic resonance imaging. Under most circumstances, there will be a much greater number of carriers than affected animals in a population. It is important to eliminate such carriers from a breeding population since they represent a hidden reservoir of the disease that can produce affected dogs at any time. The test is available now and information on submitting samples is given below. Breeders will be sent results identifying their dog as belonging to one of three categories: CLEAR: the dog has 2 copies of the normal gene and will neither develop L-2-HGA, nor pass a copy of the L-2-HGA gene to any of its offspring. CARRIER: the dog has one copy of the normal gene and one copy of the mutant gene that causes L-2-HGA. It will not develop L-2-HGA but will pass on the L-2-HGA gene to 50% (on average) of its offspring. AFFECTED: the dog has two copies of the L-2-HGA mutation and is affected with L-2-HGA. It will develop L-2-HGA at some stage during its lifetime, assuming it lives to an appropriate age. Carriers can still be bred to clear dogs. On average, 50% of such a litter will be clear and 50% carriers; there can be no affecteds produced from such a mating. Pups which will be used for breeding can themselves be DNA tested to determine whether they are clear or carrier. This test requires 2mls EDTA blood. Samples should be sent together with a completed DNA Testing form and payment of £63 inc VAT ( cheque or credit card) for each sample to Genetic Services, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU.                 STAFFORDSHIRE BULL TERRIERS INFO: PRIVACY POLICY.                     Other Well Known Links. www.staffords.co.uk www.ssbtc.co.uk Scottish Staffordshire Bull Terrier Dog Rescue Website Designed and Optimised by Aberdeen Website Design please follow the link below?

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